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Whole-genome duplication shaped cell-type evolution in the vertebrate brain

✇Nature
di: Yuanzhen Zhu · Shuai Zhang · Jiankai Wei · Diego Dolgetta-Garcia · Katia Jindrich · Huimin Liu · Chenggang Shi · Rongrong Pan · Yuwei Chen · Yan Xu · Qiye Li · Günter P. Wagner · Peter W. H. Holland · Guang Li · Sebastian M. Shimeld

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10629-x

Analyses of brain single-cell transcriptomes from human, mouse, lizard, lamprey and amphioxus reveal that duplicated genes (ohnologues) played a pivotal part in early vertebrate cell-type diversification.
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Whole-genome duplication shaped cell-type evolution in the vertebrate brain

✇Nature - Issue - nature.com science feeds
di: Yuanzhen Zhu · Shuai Zhang · Jiankai Wei · Diego Dolgetta-Garcia · Katia Jindrich · Huimin Liu · Chenggang Shi · Rongrong Pan · Yuwei Chen · Yan Xu · Qiye Li · Günter P. Wagner · Peter W. H. Holland · Guang Li · Sebastian M. Shimeld

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10629-x

Analyses of brain single-cell transcriptomes from human, mouse, lizard, lamprey and amphioxus reveal that duplicated genes (ohnologues) played a pivotal part in early vertebrate cell-type diversification.
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