Accedi
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10613-5
Molecular glue degraders of the RNA-binding protein HuR have therapeutic potential for BRAF-mutant cancers.
Modalità di lettura
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10633-1
Linafexor is a rapidly cleared FXR agonist designed to mimic natural bile acid signalling, achieving transient receptor activation with strong efficacy and reduced toxicity in preclinical and early clinical studies.
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10613-5
Molecular glue degraders of the RNA-binding protein HuR have therapeutic potential for BRAF-mutant cancers.
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10633-1
Linafexor is a rapidly cleared FXR agonist designed to mimic natural bile acid signalling, achieving transient receptor activation with strong efficacy and reduced toxicity in preclinical and early clinical studies.