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Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6

✇Nature
di: Xiao Fan · Jian Huang · Lin Yang · Jiaofeng Chen · Huan Wang · Xiaoshuang Huang · Jinli Geng · Qinglin Wu · Yuzhen Xie · Fangzhou Lu · Qinmeng Guo · Zilin Shen · Xueqin Jin · Nieng Yan

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10661-x

Structures of the distinct binding poses of three agonistic peptide toxins—bullet-ant-derived toxin δ-paraponeritoxin-Pc1a, cone snail ι-conotoxin RXIA and the globular β-scorpion toxin Cn2—on the human Nav1.6–β1 channel complex illustrate a diversity in binding poses and mechanisms of action.
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Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6

✇Nature - Issue - nature.com science feeds
di: Xiao Fan · Jian Huang · Lin Yang · Jiaofeng Chen · Huan Wang · Xiaoshuang Huang · Jinli Geng · Qinglin Wu · Yuzhen Xie · Fangzhou Lu · Qinmeng Guo · Zilin Shen · Xueqin Jin · Nieng Yan

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10661-x

Structures of the distinct binding poses of three agonistic peptide toxins—bullet-ant-derived toxin δ-paraponeritoxin-Pc1a, cone snail ι-conotoxin RXIA and the globular β-scorpion toxin Cn2—on the human Nav1.6–β1 channel complex illustrate a diversity in binding poses and mechanisms of action.
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Author Correction: A broadly protective antibody targeting gammaherpesvirus gB

✇Nature - Issue - nature.com science feeds
di: Cong Sun · Chu Xie · Bing-Zhen Cheng · Zi-Ying Jiang · Pei-Huang Wu · Xin-Yan Fang · Peng-Lin Li · Xian-Shu Tian · Hang Zhou · Yan-Lin Yang · Jing Wang · Sen-Fang Sui · Zheng Liu · Mu-Sheng Zeng

Nature, Published online: 09 June 2026; doi:10.1038/s41586-026-10745-8

Author Correction: A broadly protective antibody targeting gammaherpesvirus gB
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