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Modalità di lettura

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Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer

✇Nature - Issue - nature.com science feeds
di: Xiaocui Lu · Xiuyun Wang · Zheng Yang · Xusheng Wang · Lin Wang · Chunhui Xu · I-Chung Lo · Chenlu Geng · Yisheng Pu · Keyu Zhang · Ziqiang Zhu · Lanxin Ye · Jiayuan Huang · Xiaofan Wei · Fang Bai · Yanan Zhu · Xiaobing Qian · Hao Dou · Hexiu Su · Yong Cang

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10613-5

Molecular glue degraders of the RNA-binding protein HuR have therapeutic potential for BRAF-mutant cancers.
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A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases

✇Nature - Issue - nature.com science feeds
di: Yi Zang · Jingjing Shi · Guanguan Zhao · Bixi Tang · Mingliang Liu · Benqiang Yao · Gaihong Wang · Hualing Pan · Shengsheng Yang · Rong Deng · Yishuang Zhao · Zhenwei Zhang · Hao-Ran Guo · Dan-Dan Sun · Hanlin Wang · Lixin Gao · Jinghua Yu · Xingxing Diao · Yong Li · Jia Li · H. Eric Xu

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10633-1

Linafexor is a rapidly cleared FXR agonist designed to mimic natural bile acid signalling, achieving transient receptor activation with strong efficacy and reduced toxicity in preclinical and early clinical studies.
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