Modalità di lettura

Glucose-responsive probiotics for glycaemic modulation in mice and monkeys

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10909-6

Engineered probiotics equipped with a synthetic glucose-responsive circuit transiently colonize the gut and secrete therapeutic factors when glucose levels increase, enabling safe, oral, sense-and-respond control of diabetes in mouse and primate models.
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Temporal uncoupling of radial glia lineage progression in cortical organoids

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10916-7

RGP lineage tracing in stem-cell-derived organoids shows highly plastic proliferation and reduced clonal neuronal diversity, indicating that missing non-cell-autonomous niche cues are essential for faithful temporal control of cortical lineage progression.
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Shared principles of human and bacterial antiviral immunity

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10756-5

The Review describes shared ancient, conserved mechanisms between human antiviral immunity and bacterial anti-phage systems, outlining universal principles of pathogen sensing, signalling and effector function that reveal common rules governing host–virus interactions across life.
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Cascading continental-scale floods across Europe in 1342–1343

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10888-8

Tracing cascading continental-scale medieval megafloods across Europe indicates that current flood management is unprepared for such sequences, highlighting the urgent need for proactive flood risk management strategies that account for unusual series of extreme flood events.
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Procognitive restoration of PV neuron plasticity in neurodevelopmental disorders

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10907-8

Expression of Meis2 in hippocampal parvalbumin-expressing interneurons in an adult mouse model of neurodevelopmental disorders rescues experience-dependent plasticity, improves memory and network function and suppresses seizures.
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Towards an equitable future of global photovoltaic waste recycling

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10905-w

Global photovoltaic waste will reach 297–402 million tonnes by 2060, and regionally adapted recycling strategies and international cooperation will be needed to provide equitable and scalable PV waste circularity.
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Luminescent-reaction-enabled super-resolution imaging

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10889-7

A new chemistry-based super-resolution imaging framework is described, enabling 3D, laser-free, highly sensitive and ultralong-term imaging of live cells which overcomes the limitations in spatiotemporal resolution associated with reaction-based imaging methods.
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Degree-of-polarization modulation for high-dimensional optical computing

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10891-z

By engineering the statistics of light at the micrometre scale using phase-only spatial light modulators, both the state and degree of polarization become spatially programmable, enabling direct encoding of information in a high-dimensional space.
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Neural basis of compositional control

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10896-8

Behaviour of human participants in a prey-pursuit task reflects dynamic blending of goal-specific control policies, with hippocampus estimating latent states, anterior cingulate cortex orchestrating policy switches and orbitofrontal cortex supplying value-based contextualization rather than driving continuous policy updating.
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Structural mechanism governing the directionality of bridge recombination

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10903-y

Cryo-electron microscopy structures show how IS621 bridge recombinase mediates DNA excision, explaining its natural preference for insertion and informing the design of programmable bridge-editing technologies.
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Species intraspecific variation drives tropical forest drought resistance

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10870-4

Substantial intraspecific variation, together with species turnover, drives coordinated shifts in drought resistance such as increased embolism resistance and wider stomatal safety margins in drier forests.
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Numerous bow shocks in the outer Helix Nebula

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10724-z

Shocks in the eastern outskirts of the Helix Nebula, detected in Hα emission with the MOTHRA telescope, provide evidence for the recycling of fragmented stellar ejecta into the surrounding gas.
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Evidence for the first globular cluster stellar stream beyond the Milky Way

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10878-w

Deep Hubble Space Telescope imaging of the ultra-diffuse galaxy UGC 9050-Dw1 reveals an extragalactic globular cluster stream, with analysis and modelling probing the rich dark matter content of the host galaxy.
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Heterogeneous climatic controls on tropical-forest biomass

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10880-2

An analysis of the relationships between aboveground biomass and various climatic factors in three major regions of tropical forest shows that understanding the complex interactions between climate, topography and soils is crucial to predict how climate change will affect carbon storage capacity.
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Superconducting 2D cuprate with a single CuO<sub>2</sub> plane

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10857-1

A high-quality, pristine monolayer cuprate superconductor with a single CuO2 plane is fabricated and used to identify two quantum critical phenomena emerging between the Mott insulating phase and the superconducting phase.
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How the human brain can pursue two goals at the same time

Nature, Published online: 12 August 2026; doi:10.1038/d41586-026-02395-7

In the natural world, an animal can blend strategies so it can advance towards several goals at the same time. An engineering approach called control theory was used to infer people’s goals while they played a simple video game, and showed how three brain regions work together to implement goal blending.
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Human brain stimulation engages different gene programs in different cell types

Nature, Published online: 12 August 2026; doi:10.1038/d41586-026-02473-w

Electrical stimulation of the human brain is a promising strategy for slowing cognitive decline. The discovery of cell-type-specific gene programs that are induced in tandem with the activity of networks of neurons in the temporal cortex when it is stimulated could inform the development of therapeutic approaches using stimulation.
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Ultrafast temporal engineering of optical properties using terahertz light

Nature, Published online: 12 August 2026; doi:10.1038/d41586-026-02478-5

A photonic time crystal is an optical system of which properties such as its refractive index are modulated strongly and rapidly over time. One has now been obtained all-optically by delivering an intense terahertz light wave onto a material with a specialized microstructure that hosts collective waves of electrons known as plasmons.
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Bow shocks reveal how a dying star returns matter to interstellar space

Nature, Published online: 12 August 2026; doi:10.1038/d41586-026-02159-3

Deep imaging of ionized gas in the Helix Nebula uncovers many curved shock waves around a dying Sun-like star. These ‘bow shocks’ are produced when ejected shells of stellar material break up and race outwards. Their changing shapes imply that the shell fragments are being stripped, shredded and mixed into interstellar gas over roughly 10,000 years.
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