❌

Modalità di lettura

Lay of the land: terrestrial conservation efforts cover a wider area than thought

Nature, Published online: 14 October 2026; doi:10.1038/d41586-026-03081-4

Governments around the world have pledged to conserve 30% of the terrestrial realm by 2030, but official data suggest that the target is barely halfway to being met. A combined global and national-level data set now shows that up to 27% of land area is conserved, but gaps in ecological representation remain.
  •  

Large blind test of methane-detecting satellites lends credibility to emissions data

Nature, Published online: 14 October 2026; doi:10.1038/d41586-026-03075-2

Twelve methane-sensing satellites were tested for their accuracy in measuring controlled-release events in the Arizona desert over a year-long blind test. Many were found to detect and quantify releases accurately, with instruments purpose-built for methane sensing performing best.
  •  

Alveolar stem cells go beyond making gas-exchange cells to repair damaged airways

Nature, Published online: 14 October 2026; doi:10.1038/d41586-026-03085-0

Alveolar type 2 (AT2) cells are the stem cells of the lung’s air sacs and are responsible for maintaining alveolar structure and gas exchange. A study that tracked AT2 cells shows that, after injury to the airway, they can also migrate between lung compartments and become bronchiolar cells to help repair damaged airways.
  •  

Evidence for multi-Li<sup>+</sup> clustering in lithium-ion battery electrolytes

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11138-7

Machine-learning-enabled atomistic simulations, spectroscopy, electrochemical data and quantum-chemical calculations reveal previously unstudied multi-lithium-ion complexes without bound anions, improving understanding of lithium-ion-battery functionality at the atomic level.
  •  

Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11176-1

A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells.
  •  

<i>Elp1</i> is required for myeloid differentiation and brain repopulation

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11112-3

Primary cultured haematopoietic stem and progenitor cells are used to analyse the molecular mechanisms of brain myeloid differentiation, and this platform enabled the identification of elongation factor ELP1 as an important regulator of this process.
  •  

Modelling mouse embryogenesis from chemically induced totipotent stem cells

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11164-5

A mouse embryo model derived from chemically induced totipotent-like stem cells progresses through key developmental milestones, including gastrulation, embryonic axis formation, haematopoiesis and early organogenesis.
  •  

Competing mechanisms toughen bcc binary and medium-entropy alloys at 20 K

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11065-7

The mechanical properties of medium-entropy alloys at 20 K show a plateau in tensile yield strength and fracture toughness as a function of temperature, with no apparent ductile-to-brittle transition.
  •  

Parity-dependent coupling of molecular spin chains to a superconductor

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11117-y

Scanning tunnelling spectroscopy shows that the fractional spin-1/2 end states of molecular Haldane chains couple differently to a superconducting condensate depending on whether the chain contains an even or odd number of spin-1 triangulene units.
  •  

Capillary-selective vasodilation through myosin inhibition halts ischaemic cascades

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11171-6

R(+)2501 reverses capillary no-reflow by relaxing pericytes, restoring microvascular perfusion and improving survival in animal models of myocardial infarction and acute kidney injury.
  •  

De novo design of cysteine proteases

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11143-w

De novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.
  •  

Computational design of metalloproteases

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11167-2

RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable proteases with potential applications in therapeutics, biotechnology and bioremediation.
  •  

Divergent genomic evolution in astrocytomas and oligodendrogliomas

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11150-x

Longitudinal genomic analyses in patients with astrocytoma or oligodendrioglioma suggest that these two types of tumour differ in the mechanisms by which they become resistant to treatment, with astrocytomas accumulating copy-number alterations and chromosomal instability markers but oligodendrogliomas acquiring new driver mutations.
  •  

Rh<sup>3+</sup> stabilized in KRh@MFI catalyses regioselective hydroformylation

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11136-9

DFT investigations combined with spectroscopic and catalytic studies of disrupted subnanometric Rh2O3 clusters show that Rh+ centres in a zeolite-based catalyst are blocked with N-containing molecules, whereas Rh3+ sites are stabilized, allowing hydroformylation reactions with enhanced regioselectivity and efficiency.
  •  

Targeted stimulation of motor cortex ensembles drives learned movements

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11174-3

Optogenetic stimulation of motor-cortex neuron ensembles shows that precisely timed activity in the primary motor cortex can generate learned neural patterns and movements, demonstrating an active role in skilled motor control.
  •  

Artificial intelligence-enabled clinical phenotyping of human brown fat

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11162-7

Artificial intelligence-enabled quantification and analyses of brown adipose tissue (BAT) activity uncover links between BAT and a healthier metabolic profile along with lower rates of psychiatric disease, and can identify pharmacologic agents that could be repurposed to activate this tissue in humans.
  •  

Early tetrapod neck mobility modelled using an extant analogue

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11158-3

Biomechanical analysis of several early tetrapods using sturgeon as an analogue revealed that early tetrapods had limited neck mobility despite separation of the head and shoulders.
  •  

Intrinsic physicochemical activity at microplastic–water interfaces

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11141-y

Commodity microplastics exhibit intrinsic physicochemical activity at water interfaces, manifested by spontaneous generation of reactive oxygen species, challenging the prevailing paradigm of plastic inertness, with implications for human health and the environment.
  •  

Hidden reaction pathways inform additive engineering for perovskite LEDs

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11120-3

Resolution and control of the hidden solution-phase chemistry of 5-aminovaleric acid added to perovskite precursor solutions is described for producing films with a near-unity mean peak photoluminescence quantum yield and near-infrared perovskite LEDs with enhanced external quantum efficiencies.
  •  

Clasping folds enable superior elastic strength of graphene films

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11109-y

Two-dimensional graphene films with unusual folded surfaces are synthesized through a modular assembly strategy and show enhanced strength, toughness and elastic strain owing to stress distribution between interlayer folds.
  •  

Wave coarsening drives time crystallization in mechatronic metamaterials

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11163-6

Wave coarsening in active elastic media is a phenomenon in which vibrations spontaneously increase in wavelength, period and amplitude before forming a globally synchronized time crystal.
  •  

Sexual dimorphism in epidermal stem cell dynamics

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11159-2

Long-term live imaging of adult mouse ear skin reveals sex-specific differences in the clonal dynamics of epidermal stem cells and transit-amplifying cells during homeostasis.
  •  

Interhemispheric monsoon dynamics over the past 450,000 years

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11166-3

A 450 ka Andean speleothem record shows Southern and Northern Hemisphere monsoons generally vary out of phase, but occasionally synchronize during rapid climate change and glacial terminations.
  •  
  •  

Educational intervention can rewire village social networks

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11154-7

A randomized controlled trial involving a health-education intervention in rural villages in Honduras shows that the intervention changed social network connections, including not only health-related connections but also friendships and financial ties.
  •  

Advancing subseasonal forecasting with machine learning

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11126-x

The AI framework probabilistic bias correction is shown to correct weather forecast errors 2 to 6 weeks ahead and boost forecast skill, making it promising for improved extreme-weather prediction.
  •  

Jurassic flightless bird reveals early ecological diversity of avialans

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-10972-z

A fossil bird from the Upper Jurassic Zhenghe Fauna of southeastern China contemporary with Archaeopteryx and that clearly could not fly sheds new light on the ecological diversification of early-diverging avialans.
  •  
❌