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CFAP20 salvages arrested RNAPII from the path of co-directional replisomes

βœ‡Nature
di:Sidrit Uruci Β· Daphne E. C. Boer Β· Paul W. Chrystal Β· Maxime Lalonde Β· Andreas Panagopoulos Β· George Yakoub Β· Idil KirdΓΆk Β· Klaas de Lint Β· Melanie van der Woude Β· Tiemen J. Wendel Β· Sem J. Brussee Β· Annelotte P. Wondergem Β· Nila K. van Overbeek Β· Nini Schotman Β· Jolanthe Lingeman Β· Mats Ljungman Β· Alexander van Oudenaarden Β· Haico van Attikum Β· Alfred C. O. Vertegaal Β· Sylvie M. Noordermeer Β· Rob M. F. Wolthuis Β· Matthias Altmeyer Β· Stephan Hamperl Β· Vincent Tropepe Β· Jeroen van den Berg Β· Diana van den Heuvel Β· Martijn S. Luijsterburg

Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09943-7

CFAP20 has a key role in rescuing RNA polymerase II complexes that have arrested during DNA transcription, limiting the accumulation of R-loops and preventing collisions between the transcription and replication machinery.
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CFAP20 salvages arrested RNAPII from the path of co-directional replisomes

βœ‡Nature - Issue - nature.com science feeds
di:Sidrit Uruci Β· Daphne E. C. Boer Β· Paul W. Chrystal Β· Maxime Lalonde Β· Andreas Panagopoulos Β· George Yakoub Β· Idil KirdΓΆk Β· Klaas de Lint Β· Melanie van der Woude Β· Tiemen J. Wendel Β· Sem J. Brussee Β· Annelotte P. Wondergem Β· Nila K. van Overbeek Β· Nini Schotman Β· Jolanthe Lingeman Β· Mats Ljungman Β· Alexander van Oudenaarden Β· Haico van Attikum Β· Alfred C. O. Vertegaal Β· Sylvie M. Noordermeer Β· Rob M. F. Wolthuis Β· Matthias Altmeyer Β· Stephan Hamperl Β· Vincent Tropepe Β· Jeroen van den Berg Β· Diana van den Heuvel Β· Martijn S. Luijsterburg

Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09943-7

CFAP20 has a key role in rescuing RNA polymerase II complexes that have arrested during DNA transcription, limiting the accumulation of R-loops and preventing collisions between the transcription and replication machinery.
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