Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09965-1

Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

Nature, Published online: 14 January 2026; doi:10.1038/s41586-025-09965-1

Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.