Modalità di lettura

Glucose-responsive probiotics for glycaemic modulation in mice and monkeys

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10909-6

Engineered probiotics equipped with a synthetic glucose-responsive circuit transiently colonize the gut and secrete therapeutic factors when glucose levels increase, enabling safe, oral, sense-and-respond control of diabetes in mouse and primate models.
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Temporal uncoupling of radial glia lineage progression in cortical organoids

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10916-7

RGP lineage tracing in stem-cell-derived organoids shows highly plastic proliferation and reduced clonal neuronal diversity, indicating that missing non-cell-autonomous niche cues are essential for faithful temporal control of cortical lineage progression.
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Rb-driven transcription limits its tumour-suppressive effects in breast cancer

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10886-w

CDK4/6 inhibition redirects Rb chromatin occupancy to activate oestrogen-responsive genes, counteracting its own ability to maintain therapeutic cell-cycle arrest.
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Procognitive restoration of PV neuron plasticity in neurodevelopmental disorders

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10907-8

Expression of Meis2 in hippocampal parvalbumin-expressing interneurons in an adult mouse model of neurodevelopmental disorders rescues experience-dependent plasticity, improves memory and network function and suppresses seizures.
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Towards an equitable future of global photovoltaic waste recycling

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10905-w

Global photovoltaic waste will reach 297–402 million tonnes by 2060, and regionally adapted recycling strategies and international cooperation will be needed to provide equitable and scalable PV waste circularity.
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Luminescent-reaction-enabled super-resolution imaging

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10889-7

A new chemistry-based super-resolution imaging framework is described, enabling 3D, laser-free, highly sensitive and ultralong-term imaging of live cells which overcomes the limitations in spatiotemporal resolution associated with reaction-based imaging methods.
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Degree-of-polarization modulation for high-dimensional optical computing

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10891-z

By engineering the statistics of light at the micrometre scale using phase-only spatial light modulators, both the state and degree of polarization become spatially programmable, enabling direct encoding of information in a high-dimensional space.
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Neural basis of compositional control

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10896-8

Behaviour of human participants in a prey-pursuit task reflects dynamic blending of goal-specific control policies, with hippocampus estimating latent states, anterior cingulate cortex orchestrating policy switches and orbitofrontal cortex supplying value-based contextualization rather than driving continuous policy updating.
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Structural mechanism governing the directionality of bridge recombination

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10903-y

Cryo-electron microscopy structures show how IS621 bridge recombinase mediates DNA excision, explaining its natural preference for insertion and informing the design of programmable bridge-editing technologies.
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Superconducting 2D cuprate with a single CuO<sub>2</sub> plane

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10857-1

A high-quality, pristine monolayer cuprate superconductor with a single CuO2 plane is fabricated and used to identify two quantum critical phenomena emerging between the Mott insulating phase and the superconducting phase.
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Glucose-responsive probiotics for glycaemic modulation in mice and monkeys

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10909-6

Engineered probiotics equipped with a synthetic glucose-responsive circuit transiently colonize the gut and secrete therapeutic factors when glucose levels increase, enabling safe, oral, sense-and-respond control of diabetes in mouse and primate models.
  •  

Temporal uncoupling of radial glia lineage progression in cortical organoids

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10916-7

RGP lineage tracing in stem-cell-derived organoids shows highly plastic proliferation and reduced clonal neuronal diversity, indicating that missing non-cell-autonomous niche cues are essential for faithful temporal control of cortical lineage progression.
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Procognitive restoration of PV neuron plasticity in neurodevelopmental disorders

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10907-8

Expression of Meis2 in hippocampal parvalbumin-expressing interneurons in an adult mouse model of neurodevelopmental disorders rescues experience-dependent plasticity, improves memory and network function and suppresses seizures.
  •  

Towards an equitable future of global photovoltaic waste recycling

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10905-w

Global photovoltaic waste will reach 297–402 million tonnes by 2060, and regionally adapted recycling strategies and international cooperation will be needed to provide equitable and scalable PV waste circularity.
  •  

Luminescent-reaction-enabled super-resolution imaging

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10889-7

A new chemistry-based super-resolution imaging framework is described, enabling 3D, laser-free, highly sensitive and ultralong-term imaging of live cells which overcomes the limitations in spatiotemporal resolution associated with reaction-based imaging methods.
  •  

Degree-of-polarization modulation for high-dimensional optical computing

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10891-z

By engineering the statistics of light at the micrometre scale using phase-only spatial light modulators, both the state and degree of polarization become spatially programmable, enabling direct encoding of information in a high-dimensional space.
  •  

Neural basis of compositional control

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10896-8

Behaviour of human participants in a prey-pursuit task reflects dynamic blending of goal-specific control policies, with hippocampus estimating latent states, anterior cingulate cortex orchestrating policy switches and orbitofrontal cortex supplying value-based contextualization rather than driving continuous policy updating.
  •  

Structural mechanism governing the directionality of bridge recombination

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10903-y

Cryo-electron microscopy structures show how IS621 bridge recombinase mediates DNA excision, explaining its natural preference for insertion and informing the design of programmable bridge-editing technologies.
  •  

Superconducting 2D cuprate with a single CuO<sub>2</sub> plane

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10857-1

A high-quality, pristine monolayer cuprate superconductor with a single CuO2 plane is fabricated and used to identify two quantum critical phenomena emerging between the Mott insulating phase and the superconducting phase.
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Could the rise of left-wing Democrats reshape America’s policy on China?

The Democratic Party’s ascendant left wing is likely to push American foreign policy further “inward” and away from big-power rivalry, according to a Chinese political scientist. Meng Weizhan, an assistant research professor at Fudan University’s Institute for Advanced Study in Social Sciences in Shanghai, also said it was time for Beijing to move away from the notion that all American political factions took a hard line on China. The remarks come as progressive Democrats are riding a wave of...

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China prepares to mark Jiang Zemin centenary with full commemorative honours

Beijing has started airing a flagship documentary on former Chinese president Jiang Zemin as part of commemorative events marking the centenary of his birth, expected to culminate on Monday in a grand ceremony presided over by President Xi Jinping. In the lead-up to the anniversary, state broadcaster CCTV launched a 12-episode documentary titled Jiang Zemin, with the network’s flagship CCTV-1 airing two episodes nightly at prime time from Tuesday. The series is jointly produced by the ruling...

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Fishing trip mishap or grey-zone test? Taiwan arrests men after boat slips past defences

Two people from mainland China were arrested six days after illegally landing in Taiwan by inflatable boat, raising fresh concerns over the island’s coastal security amid its biggest annual military drill. The timing of the incident has drawn scrutiny. The two men arrived just before the 10-day Han Kuang exercise, which began on August 5, and remained at large for nearly a week before being arrested. The case only came to light on Monday after an angler reported finding an abandoned inflatable...

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